Dr. Martha Carletti

Dr. Carletti于2003年在William Jewell学院获得分子生物学学士学位, 并于2009年在堪萨斯大学医学中心获得分子和综合生理学博士学位.  在堪萨斯大学医学中心做过一段时间的博士后研究研究乳腺癌之后, Dr. 卡莱蒂在家里和她的三个孩子呆了几年，并做了一些兼职教学.  After realizing that teaching was her passion, Dr. 2014年，卡莱蒂接受了本尼迪克特学院的一个职位.  她与丈夫和三个孩子住在密苏里州的韦斯顿.  In her free time, she loves to run marathons, travel with her family to National Parks, cheer her kids on at all their sporting events, and hang out with the family boxer dog, Chip.

Classes

Anatomy and Physiology 1 & 2

Immunology

Cell Physiology

Principles of Biology

Education

Doctor of Philosophy (2009)

Molecular and Integrative Physiology

堪萨斯大学医学中心，堪萨斯城，堪萨斯

论文题目:microrna介导的卵巢功能转录后基因调控

Bachelor of Science (2003)

Oxbridge Honors Program: Molecular Biology

William Jewell College, Liberty, MO

Research Project

与堪萨斯大学医学中心和美国宇航局合作, 我正在做一个研究微重力对老鼠生理影响的项目. 卵巢功能的年龄依赖性下降会影响卵巢雌二醇的产生，而雌二醇的产生反过来又在维持正常的体内平衡和肌肉代谢过程中起关键作用, bone, neural, immune, cardiovascular and the reproductive system. 因此，太空飞行对卵巢雌二醇产生的影响对于理解任何和所有在太空中使用雌性小鼠的实验至关重要. This project investigates variations in ovarian, uterine, adrenal, 以及在地球上长大的老鼠和在国际空间站上长时间生活的老鼠的阴道组织(通过组织学染色检查).  该项目的研究成果在2019年丹佛举行的美国引力与空间研究学会年会上发表, Colorado).

Publications

Carletti, M.Z., Christenson, L.K. MicroRNA-21 Enhances Global Translation. In preparation.

Elsarraj, H.S., Hong, Y., Valdez, K., Carletti, M.Z., Salah, S.M., Raimo, M., Taverna, D., Prochasson, P., Bharadwaj, U., Tweardy, D.J., Christenson, L.K., Behbod, F.  2013.  microRNA-146b在促进乳腺泡祖细胞维持中的新作用.” Journal of Cell Science.  126:2446-58.

Kittrell F.S., Carletti M.Z., Kerbawy S., Heestand J., Xian W., Zhang M., Lamarca H.L., Sonnenberg A., Rosen J.M., Medina D., Behbod F. 2011.  从具有形态发生潜力的永生化小鼠乳腺上皮细胞中分离和鉴定稳定和多能祖细胞.”  Breast Cancer Res. Apr 5:13(2):R41.

Pal, A., Valdez, K.E., Carletti, M.Z., Behbod, F. 2010. 靶向犯罪者:癌症干细胞疗法.” Current Drug Targets, Sep;11(9): 1147-56.

Carletti, M.Z., Fiedler, S.D., Christenson, L.K. 2010. LH诱导MicroRNA-21阻断颗粒细胞凋亡.” Biology of Reproduction Aug 1;83(2):286-95.

Park, E., Choi, S., Lind, A., Dahm-Kahler, P., Brannstrom, M., Carletti, M.Z., Christenson, L.K., Curry, T.E., Jo, M. 2010. RUNX2转录因子调控大鼠卵巢黄体生成素颗粒细胞基因表达.” Mol. Endocrinol. Apr;24(4):846-58.

Fiedler, S.D., Carletti, M.Z.,Christenson, L.K. 2010. 成熟MicroRNA表达分析的定量RT-PCR方法.  Methods Mol. Biol. 630:49-64.

Constantineau, J., Greason, E., West M., Filbin M., Kieft J.S., Carletti, M.Z., Christenson, LK, Rodriguez, A. 2010. 清除者受体内的同义外显子8变体(rs5888), Class B, 1型基因与体外低SR-B1蛋白表达及功能相关.” Atherosclerosis. May;210(1):177-82.

Luense, L.J., Carletti, M.Z., Christenson, L.K. 2009. “Role of Dicer in Female Fertility.” Trends in Endocrinology and Metabolism. Aug;20(6):265-72.

Carletti, M.Z., Christenson, L.K. 2009. 促黄体生成素对小鼠卵泡壁颗粒细胞基因表达的快速影响.” Reproduction. May;137(5):843-55.

Fiedler, S.D., Carletti, M.Z., Christenson, L.K. 2009. 成熟MicroRNA表达分析的定量RT-PCR方法.RT-PCR协议，第2版:分子生物学方法，编辑Nicola King. 

Holets, L.M., Carletti, M.Z., Kshirsagar, S.K., Christenson, L.K., Petroff, M.G. 2009. 人滋养细胞B7-H1分化诱导的转录后调控.” Placenta. Jan;30(1):48-55.

Carletti, M.Z.,Christenson, L.K. 2008. MicroRNA in the Ovary and Female Reproductive Tract. Journal of Animal Science. Apri;87(14 Suppl):E29-38.

Fiedler, S.D., Carletti, M.Z., Hong, X., Christenson, L.K. 2008. 排卵期小鼠壁粒细胞中MicroRNA表达的激素调控.” Biol Reprod. Dec;79(6):1030-7.

Discovery Day Projects

2019-2020 Discovery Day Projects

微重力环境对小家鼠阴道和子宫组织影响的评价. Nicholas Brose, Graham Griesdale, Aidan de Moulpied, Amara Feyrer-Melk, Danielle Rumsey, Peter Schultz, Sophia Debenedetti.

研究损伤:运用运动和肌筋膜松解治疗上交叉综合征的疗效分析. Natalie Ruether, Sophia Holm, Emily Fennewald. **Finalist for Wangari Matthai Award

微重力对小鼠子宫炎症标志物的影响. Erin Rauber, Molly Muehlebach, Brynn Maul, Matthew Piontek, Ella Majerus.

送往国际空间站的小鼠肾上腺皮质和髓质的大小. Megan Nault and Lillian Nacke.

Investigation of the Color Spectrum. Johnathan Torgerson, Kyle Eckart.

大学生出国医疗旅行的目的、伦理与有效性分析. Ryan Werdel. **Winner of Wangari Matthai Award

2018-2019 Discovery Day Projects

The Effect of Hydrazine Sulfate on Cancer Cells In Vitro. Joseph Marak, Eva Pecha, Daniela Garcia-Perez, Mark Abegg, Martha Carletti.

Rosemary and Its Effect on Cervical Cancer Cells in Vitro. 萨拉·拉赫曼扎伊，梅根·诺特，莉莲·纳克，凯瑟琳·韦弗，梅根·麦克莱伦，玛莎·卡莱蒂

白藜芦醇的遗传毒性和凋亡作用. Erin Rauber, Molly Muehlebach, Brynn moore, Mikaela Loucks, Martha Carletti.

2017-2018 Discovery Day Projects

The Antioxidant Effects of Protandim. Eden Anderson, Will Argana, Michaela Dreiling, Matthew Jarecki, Kolbe Poarch, Martha Carletti.

SR9243对HeLa细胞增殖和凋亡的影响. Jacob Cushing, Lane Fry, Jude Severson, Erin Rauber, Martha Carletti.

2016-2017 Discovery Day Projects

SR9243对HeLa细胞增殖能力的影响 In Vitro Through the Use of a MTT Assay. Brandon Betsch, Jacob Cushing, Martha Carletti.

CCR5-Δ32本尼迪克特学院的突变和免疫系统相关疾病. Jacob Cushing, Martha Carletti.

Protandim对活性氧和DNA突变率的影响. Eden Anderson, Kira Alexander, Kristen Hylen, laurence Ouedraogo, Martha Carletti.

2015-2016 Discovery Day Projects

Barrett食管上皮细胞与正常食管上皮细胞中主要Vault蛋白的比较. Kristen Hylen, Julia Hemman, Martha Carletti.

Barrett食管细胞与食管腺癌之间QK1蛋白水平的升高. 布兰登·贝奇，杰西卡·林顿，詹妮弗·吉尔伯特，玛莎·卡莱蒂.

Comparison of Dicer levels of normal esophagus vs. Barrett’s. 阿纳斯塔西娅·拉特克利夫，劳伦西亚·韦德拉奥戈，玛莎·卡莱蒂.

2014-2015 Discovery Day Projects

食管癌研究:miR505和miR944在胃食管反流向巴雷特食管转移中的作用. Shannon Schrader, Teresa Lara, Martha Carletti.

胃食管反流病向巴雷特食管过渡状态的标志物鉴定. Rachel Hernandez, Shannon Groe, Martha Carletti.